Goodlettsville Dental Services

Polymorphous Low-Grade Adenocarcinoma

Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, slow-growing malignant salivary gland tumor. It is most commonly found on the palate.

The name of the tumor derives from the fact that:

• It has a varied microscopic architectural appearance, i.e. it is polymorphous.  
• It is non-aggressive when compared to other oral cavity tumors, i.e. it is a low-grade tumor.  
• It forms glands, i.e. it is an adenocarcinoma.  

Histology

PLGAs consist of a monomorphous cell population that has a varied histologic morphology.

Microscopically, its histology can be confused with an adenoid cystic carcinoma and a pleomorphic adenoma.

Treatment

PLGAs are treated with wide local surgical excision and long-term follow-up.